‘At first the pills worked and I managed to get some sleep, although at best I’d say it was poor quality,’ recalls Janet, now 53, from Wakefield, Yorkshire. ‘But my body must have quickly become tolerant to the drugs, because after a few months I started waking at night again.
‘In the morning I’d have a dreadful hangover feeling that would take most of the day to clear. I felt muzzy headed, couldn’t concentrate, and became anxious.’
Desperate to sleep well: One in ten Brits take sleeping tablets (posed by model)
It got worse. Within months of taking the pills, she lost her appetite and her weight plummeted from more than ten stone to 7½ stone (she is 4ft 11in tall). She was also plagued by headaches and dizzy spells.
‘I suffered terrible fatigue and developed terrifying heart palpitations,’ she says. When she complained to her GP about the side-effects, she was merely switched to another drug, zopiclone.
‘I was too confused to argue,’ says Janet. ‘By that stage my husband Philip had to quit his job as a joiner to help take care of our five children. I’d also become physically frail — like a woman in her 70s. I was so unsteady on my feet and frightened of falling that I wouldn’t go out.
‘The pills lost their effect and eventually I was taking two 7.5mg zopiclone pills a night.’
Janet is one of millions of Britons taking pills to get to sleep — a study last year found one in ten of us uses them. Around nine million prescriptions were written for sleeping pills (which include zolpidem, zopiclone, zaleplon and hypnotic benzodiazepines) in 2010.
'Within months of taking the pills, I suffered terrible fatigue and developed terrifying heart palpitations'
Previously, the greatest concern was about their highly addictive nature — patients are meant to take them for a maximum of four weeks, say guidelines published by the National Institute for Health and Clinical Excellence (NICE). Yet research published by King’s College London last summer found around one in five prescriptions were for longer than eight weeks.
But U.S. research published in February suggested a greater danger: the study found people taking sleeping pills had up to a five times higher risk of death.
Those given the highest doses had a 35 per cent increased risk of a major cancer. The risk of lymphomas (cancer of the lymph system), lung, colon and prostate cancers was greater than for people who smoked.
The study, published in the British Medical Journal Open, followed 10,000 patients who took sleeping pills — such as benzodiazepines (including temazepam), the so-called Z-drugs of zopiclone, zolpidem and zaleplon, and barbiturates and antihistamines with a sedative effect (usually used for people with eczema and hay fever) — and compared them with 23,000 patients who didn’t, but shared a similar health profile.
Ordeal: Janet Marshall suffered ill-health after taking zolpidem and then zopiclone
The most alarming finding was that even patients prescribed fewer than 18 pills a year had a threefold increased risk of death. Nobody knows for sure why, but possible explanations include the drugs making patients more prone to accidents or falls, or at increased risk of sleep apnoea (breathing interrupted during sleep).
Previous research has found an increased risk of suicide, car crashes and falls connected with use of insomnia pill. Other studies have found side-effects including sleep apnoea, high blood pressure, irregular heartbeat and cardiovascular disease. Sleeping pills may also cause night-time eating syndrome, leading to poor diet and obesity.
‘You only have to talk to people who have been on benzodiazepines and Z-drugs long term and they’ll tell you how badly it has affected their heath — mentally and physically,’ says Barry Haslam, founder of the patient self help group benzo.org.uk.
Indeed, the researchers in the study linking sleeping pills to a higher death rate concluded that given the ‘meagre benefits’ of the drugs ‘and the evidence of mortality risks’ it was time to ‘reconsider if even short-term use of hypnotics is safe’.
However, their research has been criticised by some pharmacists and academics.
‘It’s the Rolex watch syndrome,’ explains Nina Barnett, a pharmacist at Northwick Park Hospital, Middlesex and spokeswoman for the Royal Pharmaceutical Society. ‘Rich men wear Rolexes. Rich men also have heart attacks — but it doesn’t mean the Rolex causes the heart attack.
‘This study does not establish a causal link between hypnotics and increased risk of death. The authors also admit they were unable to get data on the actual causes of death in these patients.
‘And if you look at the data in detail, all the hypnotic users had a higher incidence of most chronic diseases including asthma, heart disease, diabetes, obesity, reflux and peptic ulcer.
'The fact that sleeping pills are still being prescribed long term makes me really angry. Doctors should be looking more carefully at the causes of insomnia'
‘We need more research — and I would certainly caution against anyone stopping their pills suddenly.’
Professor Allan Young, chairman of the Royal College Of Psychiatrists Psycho-Pharmacology Group, says: ‘These tablets have been used for 50 years, so I think if taking them caused cancer it would be obvious by now.’
Indeed, insomnia sufferer Laura Marcus says when used correctly, the drugs can really help. ‘I’ve taken zopiclone for the past four years on and off,’ says Laura, a 55-year old radio presenter from Leek, Staffordshire. ‘I haven’t had any adverse side-effects.’
‘I only take one tablet a week as a treat, as I know I’ll get a good night’s sleep.’
When you talk to the experts, their greater concern is that many people are being prescribed sleeping pills long term, causing addiction problems.
Sleeping pills can be very hard to come off because they become less effective after the first few nights — the temptation then is to increase the dose, and patients can quickly become psychologically and physically dependent on the drug. If the pills are suddenly withdrawn, this can trigger anxiety, nightmares, and even convulsions and hallucinations — and a recurrence of the sleeplessness.
Quick fix: Many people become too reliant on sleeping pills instead of addressing the real reason why they can't sleep (posed by model)
‘The fact that sleeping pills are still being prescribed long term makes me really angry,’ says Professor Young. ‘Doctors should be looking more carefully at the causes of insomnia, as very often sleep disturbance is a key component of other illnesses such as depression or a symptom of pain.’
A spokesman for the Medicines and Healthcare products Regulatory Agency, the Government’s drug safety watchdog, said there is clinical evidence benzodiazepines provide significant benefits to patients suffering the distress of severe insomnia, and that prescribing advice restricts them to short-term use.
‘However, all medicines have some side-effects, and the MHRA closely monitors the safety of benzodiazepines and all other medicines,’ the spokesman adds. ‘We are carefully considering the findings of this research.’
Only five years ago, Janet Marshall’s GP conceded she might have a problem with the sleeping pills — and she decided it was time to go cold turkey.
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